Skin Cancer Risk Factors in 2025: Who’s More Vulnerable and Why?

As global awareness of skin cancer grows, so does the understanding of the factors that increase one’s risk. In 2025, skin cancer continues to be a major health concern, especially with changing environmental conditions, shifting lifestyle habits, and advances in diagnostic tools that are highlighting new vulnerabilities. Understanding who is more at risk and why is critical in preventing and detecting skin cancer early.

According to leading dermatologist Dr Shaun Segal, “Risk factors for skin cancer are evolving with the times. Genetics still matter, but modern environmental and behavioral influences are shifting the risk landscape more than ever before.”

In this blog, we’ll explore the primary and emerging risk factors in 2025 that are making certain groups more vulnerable to skin cancer than others.

1. Excessive UV Exposure Remains the Top Risk

Ultraviolet (UV) radiation from the sun or artificial sources like tanning beds continues to be the number one cause of skin cancer. While this has been known for decades, the intensity and frequency of exposure in 2025 have increased due to lifestyle shifts. Remote working and hybrid schedules have led more people outdoors for longer periods, especially during peak UV hours.

Even on cloudy days, UV rays can penetrate the skin. Prolonged exposure without sun protection increases the risk for all skin types, particularly fair-skinned individuals who lack sufficient melanin to block harmful rays.

2. Fair Skin, Light Eyes, and Red or Blonde Hair

People with lighter complexions are more susceptible to sunburns and sun damage, which significantly raises their risk of skin cancer. This includes those with:

• Fair or pale skin
  
  
• Red or blonde hair
  
  
• Blue, green, or light-colored eyes
  
  
• Freckles or a tendency to burn rather than tan
  
  

Dr Shaun Segal explains, “Melanin acts as a natural barrier. The less melanin you have, the higher your vulnerability to UV damage and the cellular mutations that can lead to skin cancer.”

Also Read: The Role of Skin Cancer Surgeons in Treating Rare and Aggressive Types of Skin Cancer

3. History of Sunburns, Especially in Childhood

Studies continue to show that a single blistering sunburn during childhood or adolescence can double a person’s risk of developing melanoma later in life. In 2025, this remains one of the most underestimated factors, especially in families that still don’t prioritize sunscreen use or protective clothing for children.

Sunburns indicate that the skin’s DNA has already sustained damage. The more frequent the burns, the higher the cumulative damage over time.

4. Living at High Altitudes or in Sunny Climates

Geographic location plays a key role. People who live in high-altitude regions (where UV rays are stronger) or sun-drenched locations like desert or coastal areas are more vulnerable due to prolonged and intensified exposure to UV radiation.

In 2025, with climate patterns shifting and more people relocating for lifestyle or remote work opportunities, this factor is becoming even more relevant.

5. Personal or Family History of Skin Cancer

Genetics still play a significant role. If you’ve had skin cancer in the past, you’re more likely to develop it again. Likewise, a family history of skin cancer, particularly melanoma, raises your risk considerably. Genetic mutations such as CDKN2A or BRAF are often found in familial melanoma cases.

Routine skin checks are crucial for individuals with a family history. Dr Shaun Segal recommends annual dermatology visits and regular self-checks for those with genetic predispositions.

6. Weakened Immune System

People with weakened immune systems, including those undergoing chemotherapy, organ transplant recipients, or individuals with autoimmune diseases, are at increased risk. A compromised immune system has a reduced ability to detect and destroy abnormal cells, including those that may become cancerous.

This group has become a larger focus in 2025, as more individuals are on long-term immunosuppressive therapies for various chronic conditions.

7. Use of Tanning Beds

Despite decades of warnings, indoor tanning remains in use in some parts of the world. In 2025, the risk is better understood—even occasional tanning bed use significantly increases the risk of both melanoma and non-melanoma skin cancers.

The artificial UV radiation used in tanning beds can be more intense than natural sunlight, leading to deeper and more harmful skin damage.

Recommended Reading: Why Some Patients Delay Skin Cancer Surgery—and the Consequences of Waiting

8. Older Age Groups

As people age, the cumulative effects of sun exposure start to manifest. Individuals over the age of 50 are at higher risk for non-melanoma skin cancers such as basal cell carcinoma and squamous cell carcinoma. Melanoma can occur at any age but is also more common in older adults.

In 2025, the global population is aging, and with improved healthcare, people are living longer. This means that more individuals are at risk of developing skin cancer simply due to the prolonged exposure accumulated over a lifetime.

9. Men Are at Higher Risk Than Women

Statistically, men are more likely to develop skin cancer, particularly after the age of 50. They often spend more time outdoors and are less likely to use sunscreen or seek dermatological care. In 2025, healthcare professionals continue to stress the importance of skin checks for men, especially those with outdoor occupations or hobbies like fishing, hiking, or sports.

10. Exposure to Radiation or Certain Chemicals

Individuals who have undergone radiation therapy or have been exposed to arsenic, coal tar, or industrial chemicals face a heightened risk. These substances can weaken the skin’s ability to repair DNA damage, increasing the likelihood of abnormal cell growth.

In 2025, ongoing occupational safety updates are trying to minimize these exposures, but they remain relevant in certain industries and environments.

Also Read: Top 5 Skin Cancer Treatment Options in 2025: What Patients Need to Know

11. Chronic Skin Inflammation or Scars

Areas of the skin that have been chronically inflamed, burned, or scarred from previous injuries or diseases may be more susceptible to developing skin cancer. Squamous cell carcinoma, in particular, has been observed in long-standing scars or areas of persistent inflammation.

12. Lack of Sun Protection Education and Habits

Finally, one of the most preventable risk factors in 2025 is the lack of awareness and consistent sun protection habits. Despite the availability of high-SPF sunscreens and UV-protective clothing, many people still skip sun protection due to inconvenience or misinformation.

Dr Shaun Segal notes, “Education is as important as sunscreen. People need to understand not just how to protect themselves, but why it matters—every single day.”

Final Thoughts

In 2025, skin cancer risk is influenced by a complex interplay of genetic, environmental, and behavioral factors. By understanding who is most vulnerable and why, individuals can make informed decisions to reduce their risk.

Whether it’s wearing sunscreen daily, scheduling regular skin exams, or avoiding tanning beds, these preventive actions can significantly lower the chances of skin cancer. Dr Shaun Segal strongly encourages everyone—regardless of skin tone or age—to stay informed, be vigilant, and prioritize skin health all year round.